Are Elevated Vancomycin Serum Trough Concentrations Achieved Within the First 7 Days of Therapy Associated With Acute Kidney Injury in Children? | Zendy

Chad A. Knoderer | Zendy; Kristen R. Nichols | Zendy; K. C. Lyon | Zendy; Megan Veverka | Zendy; Amanda Wilson | Zendy

Open Access

Are Elevated Vancomycin Serum Trough Concentrations Achieved Within the First 7 Days of Therapy Associated With Acute Kidney Injury in Children?

Author(s) -

Chad A. Knoderer,

Kristen R. Nichols,

K. C. Lyon,

Megan Veverka,

Amanda Wilson

Publication year - 2013

Publication title -

journal of the pediatric infectious diseases society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.269

H-Index - 31

eISSN - 2048-7207

pISSN - 2048-7193

DOI - 10.1093/jpids/pit076

Subject(s) - medicine , vancomycin , rifle , acute kidney injury , creatinine , odds ratio , confidence interval , pediatric intensive care unit , renal function , intensive care unit , population , pediatrics , history , environmental health , archaeology , biology , bacteria , genetics , staphylococcus aureus

In 2008, the empiric vancomycin dosing recommendation in children at our institution was changed from 40 to 60 mg/kg per day. Subsequently, an increased incidence of acute kidney injury (AKI) in patients receiving vancomycin was suspected. The objective of this study was to evaluate AKI in children receiving vancomycin and to determine risk factors for AKI development.

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