Antiviral Drug-Resistance Typing Reveals Compartmentalization and Dynamics of Acyclovir-Resistant Herpes Simplex Virus Type-2 (HSV-2) in a Case of Neonatal Herpes | Zendy

Ma Bache | Zendy; Graciela Andreï | Zendy; L. Bindl | Zendy; Leon Bofferding | Zendy; Jean Bottu | Zendy; Christine Geron | Zendy; Claudia Neuhauser | Zendy; Sarah Gillemot | Zendy; Pierre Fiten | Zendy; Ghislain Opdenakker | Zendy; Robert Snoeck | Zendy

Open Access

Antiviral Drug-Resistance Typing Reveals Compartmentalization and Dynamics of Acyclovir-Resistant Herpes Simplex Virus Type-2 (HSV-2) in a Case of Neonatal Herpes

Author(s) -

Ma Bache,

Graciela Andreï,

L. Bindl,

Leon Bofferding,

Jean Bottu,

Christine Geron,

Claudia Neuhauser,

Sarah Gillemot,

Pierre Fiten,

Ghislain Opdenakker,

Robert Snoeck

Publication year - 2013

Publication title -

journal of the pediatric infectious diseases society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.269

H-Index - 31

eISSN - 2048-7207

pISSN - 2048-7193

DOI - 10.1093/jpids/pit045

Subject(s) - herpes simplex virus , medicine , virology , cerebrospinal fluid , hsl and hsv , virus , drug resistance , aciclovir , herpesviridae , immunology , viral disease , pathology , biology , microbiology and biotechnology

A neonate suffering from herpes simplex virus type 2 disease with central nervous system involvement developed an early recurrence under acyclovir therapy. Isolates from the cerebrospinal fluid and skin lesions were acyclovir resistant, while viruses from blood and trachea were not. Acyclovir combined with foscavir followed by long-term suppressive acyclovir therapy supported normal neurological development.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research