Multisystem Inflammatory Syndrome in Children in February 2020 and Implications of Genomic Sequencing for SARS-CoV-2 | Zendy

Emily Parsons | Zendy; M Timlin | Zendy; Clarise Starr | Zendy; Anthony C Fries | Zendy; Ronald Wells | Zendy; Matthew Studer | Zendy; Rebecca Sainato | Zendy

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Multisystem Inflammatory Syndrome in Children in February 2020 and Implications of Genomic Sequencing for SARS-CoV-2

Author(s) -

Emily Parsons,

M Timlin,

Clarise Starr,

Anthony C Fries,

Ronald Wells,

Matthew Studer,

Rebecca Sainato

Publication year - 2020

Publication title -

journal of the pediatric infectious diseases society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.269

H-Index - 31

eISSN - 2048-7207

pISSN - 2048-7193

DOI - 10.1093/jpids/piaa167

Subject(s) - medicine , covid-19 , lineage (genetic) , outbreak , coronavirus , virology , disease , immunology , infectious disease (medical specialty) , genetics , gene , biology

Multisystem inflammatory syndrome in children (MIS-C) is a newly recognized disease process that can complicate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We present what we believe to be the earliest case of MIS-C, occurring in February 2020. Our patient’s SARS-CoV-2 infection was caused by an emerging lineage with the D614G variant in the spike protein. This lineage would subsequently become the predominant cause of SARS-CoV-2 outbreaks in Europe and the United States where MIS-C was first described.

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