Systematic Review and Meta-analysis of Testicular Germ Cell Tumors Following In Utero Exposure to Diethylstilbestrol | Zendy

Marianne S. Hom | Zendy; Intira Sriprasert | Zendy; Ugonna Ihenacho | Zendy; Jose E. Castelao | Zendy; Kimberly D. Siegmund | Zendy; Leslie Bernstein | Zendy; Victoria K. Cortessis | Zendy

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Systematic Review and Meta-analysis of Testicular Germ Cell Tumors Following In Utero Exposure to Diethylstilbestrol

Author(s) -

Marianne S. Hom,

Intira Sriprasert,

Ugonna Ihenacho,

Jose E. Castelao,

Kimberly D. Siegmund,

Leslie Bernstein,

Victoria K. Cortessis

Publication year - 2019

Publication title -

jnci cancer spectrum

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.345

H-Index - 10

ISSN - 2515-5091

DOI - 10.1093/jncics/pkz045

Subject(s) - in utero , medicine , diethylstilbestrol , testicular cancer , odds ratio , hypospadias , pregnancy , gynecology , estrogen , cancer , etiology , physiology , oncology , obstetrics , fetus , surgery , biology , genetics

Results of this comprehensive meta-analysis accord with a threefold increase in testicular cancer risk among men who were exposed in utero to DES, implicating early hormonal exposures in etiology of testicular cancer. Because use of DES ceased in 1971, this work may provide the most comprehensive estimate of this association that will be made.

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