Deoxyribonuclease I Activity, Cell-Free DNA, and Risk of Liver Cancer in a Prospective Cohort | Zendy

Rachel M. Golonka | Zendy; Beng San Yeoh | Zendy; Jessica L. Petrick | Zendy; Stephanie J. Weinstein | Zendy; Demetrius Albanes | Zendy; Andrew T. Gewirtz | Zendy; Katherine A. McGlynn | Zendy; Matam Vijay–Kumar | Zendy

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Deoxyribonuclease I Activity, Cell-Free DNA, and Risk of Liver Cancer in a Prospective Cohort

Author(s) -

Rachel M. Golonka,

Beng San Yeoh,

Jessica L. Petrick,

Stephanie J. Weinstein,

Demetrius Albanes,

Andrew T. Gewirtz,

Katherine A. McGlynn,

Matam Vijay–Kumar

Publication year - 2018

Publication title -

jnci cancer spectrum

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.345

H-Index - 10

ISSN - 2515-5091

DOI - 10.1093/jncics/pky083

Subject(s) - medicine , biomarker , hazard ratio , prospective cohort study , cancer , confidence interval , liver cancer , cohort , gastroenterology , quartile , oncology , nested case control study , cohort study , odds ratio , biology , biochemistry

DNase I activity was a superior latent biomarker of liver cancer than cfDNA. These findings advance the goal of developing a means to detect liver cancer years well before the development of clinical manifestations.

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