Prospective Evaluation of the Addition of Polygenic Risk Scores to Breast Cancer Risk Models | Zendy

Sherly X Li | Zendy; Roger L. Milne | Zendy; Tú NguyenDumont | Zendy; Xiaochuan Wang | Zendy; Dallas R. English | Zendy; Graham G. Giles | Zendy; Melissa C. Southey | Zendy; Antonis C. Antoniou | Zendy; Andrew Lee | Zendy; Shuai Li | Zendy; Ingrid Winship | Zendy; John L. Hopper | Zendy; Mary Beth Terry | Zendy; Robert J. MacInnis | Zendy

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Prospective Evaluation of the Addition of Polygenic Risk Scores to Breast Cancer Risk Models

Author(s) -

Sherly X Li,

Roger L. Milne,

Tú NguyenDumont,

Xiaochuan Wang,

Dallas R. English,

Graham G. Giles,

Melissa C. Southey,

Antonis C. Antoniou,

Andrew Lee,

Shuai Li,

Ingrid Winship,

John L. Hopper,

Mary Beth Terry,

Robert J. MacInnis

Publication year - 2021

Publication title -

jnci cancer spectrum

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.345

H-Index - 10

ISSN - 2515-5091

DOI - 10.1093/jncics/pkab021

Subject(s) - medicine , polygenic risk score , breast cancer , prospective cohort study , risk assessment , oncology , medline , cancer , genetics , single nucleotide polymorphism , gene , genotype , computer security , biology , computer science , law , political science

The Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm and the International Breast Cancer Intervention Study breast cancer risk models are used to provide advice on screening intervals and chemoprevention. We evaluated the performance of these models, which now incorporate polygenic risk scores (PRSs), using a prospective cohort study.

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