Open AccessApplications of Circulating Tumor DNA in a Cohort of Phase I Solid Tumor Patients Treated With Immunotherapy
Author(s) -
Daniel Vilarim Araújo,
Ao Wang,
Dax Torti,
Alberto J. León,
Kayla Marsh,
Aoife McCarthy,
Hal K. Berman,
Anna Spreafico,
Aaron Richard Hansen,
Albiruni-Abdul Razak,
Philippe L. Bédard,
Lisa Wang,
Eric Plackmann,
Helen Chow,
Hua Bao,
Xue Wu,
Trevor J. Pugh,
Lillian L. Siu
Publication year - 2021
Publication title -
jnci cancer spectrum
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.345
H-Index - 10
ISSN - 2515-5091
DOI - 10.1093/jncics/pkaa122
Subject(s) - medicine , circulating tumor dna , oncology , immunotherapy , mutation , cohort , cancer , gene , genetics , biology
The correlation between blood-based tumor mutation burden (bTMB) and tissue-based tumor mutation burden(tTMB) has not been broadly tested in a multicancer cohort. Here, we assess the correlation between bTMB with tTMB in phase I trial patients treated with immunotherapy. As an exploratory analysis, we evaluated circulating tumor DNA (ctDNA) dynamics in responders.