Concordance of Circulating Tumor DNA and Matched Metastatic Tissue Biopsy in Prostate Cancer | Zendy

Alexander W. Wyatt | Zendy; Matti Annala | Zendy; Rahul Aggarwal | Zendy; Kevin Beja | Zendy; Felix Y. Feng | Zendy; Jack Youngren | Zendy; Adam Foye | Zendy; Paul Lloyd | Zendy; Matti Nykter | Zendy; Tomasz M. Beer | Zendy; Joshi J. Alumkal | Zendy; George Thomas | Zendy; Robert E. Reiter | Zendy; Matthew B. Rettig | Zendy; Christopher P. Evans | Zendy; Allen C. Gao | Zendy; Kim N. | Zendy; Eric J. Small | Zendy; Martin Gleave | Zendy

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Concordance of Circulating Tumor DNA and Matched Metastatic Tissue Biopsy in Prostate Cancer

Author(s) -

Alexander W. Wyatt,

Matti Annala,

Rahul Aggarwal,

Kevin Beja,

Felix Y. Feng,

Jack Youngren,

Adam Foye,

Paul Lloyd,

Matti Nykter,

Tomasz M. Beer,

Joshi J. Alumkal,

George Thomas,

Robert E. Reiter,

Matthew B. Rettig,

Christopher P. Evans,

Allen C. Gao,

Kim N.,

Eric J. Small,

Martin Gleave

Publication year - 2017

Publication title -

jnci journal of the national cancer institute

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.797

H-Index - 356

eISSN - 1460-2105

pISSN - 0027-8874

DOI - 10.1093/jnci/djx118

Subject(s) - concordance , liquid biopsy , biopsy , prostate cancer , pten , cold pcr , cell free fetal dna , pathology , cancer , medicine , biology , oncology , cancer research , gene , mutation , point mutation , genetics , apoptosis , pregnancy , fetus , pi3k/akt/mtor pathway , prenatal diagnosis

Real-time knowledge of the somatic genome can influence management of patients with metastatic castration-resistant prostate cancer (mCRPC). While routine metastatic tissue biopsy is challenging in mCRPC, plasma circulating tumor DNA (ctDNA) has emerged as a minimally invasive tool to sample the tumor genome. However, no systematic comparisons of matched "liquid" and "solid" biopsies have been performed that would enable ctDNA profiling to replace the need for direct tissue sampling.

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