PARKINInactivation Links Parkinson’s Disease to Melanoma | Zendy

HuiHan Hu | Zendy; Caroline Kannengiesser | Zendy; Suzanne Lesage | Zendy; Jocelyne André | Zendy; Samia Mourah | Zendy; Laurence Michel | Zendy; V. Descamps | Zendy; Nicole BassetSéguin | Zendy; M. Bagot | Zendy; Armand Bensussan | Zendy; Célèste Lebbé | Zendy; Lydia Deschamps | Zendy; Philippe Saïag | Zendy; M.T. Leccia | Zendy; Brigitte Bressac–de Paillerets | Zendy; A. Tsalamlal | Zendy; Rajiv Kumar | Zendy; Stephan Klebe | Zendy; Bernard Grandchamp | Zendy; Nathalie AndrieuAbadie | Zendy; L. Thomas | Zendy; Alexis Brice | Zendy; Nicolas Dumaz | Zendy; Nadem Soufir | Zendy

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PARKINInactivation Links Parkinson’s Disease to Melanoma

Author(s) -

HuiHan Hu,

Caroline Kannengiesser,

Suzanne Lesage,

Jocelyne André,

Samia Mourah,

Laurence Michel,

V. Descamps,

Nicole BassetSéguin,

M. Bagot,

Armand Bensussan,

Célèste Lebbé,

Lydia Deschamps,

Philippe Saïag,

M.T. Leccia,

Brigitte Bressac–de Paillerets,

A. Tsalamlal,

Rajiv Kumar,

Stephan Klebe,

Bernard Grandchamp,

Nathalie AndrieuAbadie,

L. Thomas,

Alexis Brice,

Nicolas Dumaz,

Nadem Soufir

Publication year - 2015

Publication title -

jnci journal of the national cancer institute

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.797

H-Index - 356

eISSN - 1460-2105

pISSN - 0027-8874

DOI - 10.1093/jnci/djv340

Subject(s) - parkin , melanoma , cancer research , biology , loss of heterozygosity , neuroblastoma ras viral oncogene homolog , tumor suppressor gene , genetics , mutation , allele , parkinson's disease , carcinogenesis , medicine , cancer , pathology , gene , disease , kras

Melanoma incidence is higher in patients affected by Parkinson's disease (PD) and vice versa, but the genetic link shared by both diseases is unknown. As PARK2 is both a tumor suppressor gene and frequently mutated in young onset PD, we evaluated the role of PARK2 in melanoma predisposition and progression.

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