Open AccessRole of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells
Author(s) -
J. Hong,
Nicholas P. Tobin,
Helene Rundqvist,
Li Tian,
Marion Lavergne,
Yaiza García-Ibáñez,
Hanyu Qin,
Janna Paulsson,
Manuel Zeitelhofer,
Milena Z. Adzemovic,
Ingrid Nilsson,
Pernilla Roswall,
Johan Hartman,
Randall S. Johnson,
Arne Östman,
Jonas Bergh,
Mirjana Poljakovic,
Guillem Genové
Publication year - 2015
Publication title -
journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/djv209
Subject(s) - pericyte , cancer research , myeloid derived suppressor cell , paracrine signalling , stromal cell , biology , tumor microenvironment , downregulation and upregulation , myeloid , s100a9 , cancer , pathology , immunology , medicine , inflammation , suppressor , endothelial stem cell , gene , tumor cells , biochemistry , receptor , in vitro
Pericytes are members of the tumor stroma; however, little is known about their origin, function, or interaction with other tumor components. Emerging evidence suggest that pericytes may regulate leukocyte transmigration. Myeloid-derived suppressor cells (MDSC) are immature myeloid cells with powerful inhibitory effects on T-cell-mediated antitumor reactivity.