Identification of Retinol Binding Protein 1 Promoter Hypermethylation in Isocitrate Dehydrogenase 1 and 2 Mutant Gliomas | Zendy

Arthur P. Chou | Zendy; Reshmi Chowdhury | Zendy; Sichen Li | Zendy; Weidong Chen | Zendy; Andrew J. Kim | Zendy; David Piccioni | Zendy; Julia Selfridge | Zendy; Reema Mody | Zendy; Stephen Chang | Zendy; Shadi Lalezari | Zendy; Jeffrey Lin | Zendy; Desiree E. Sanchez | Zendy; Ryan W. Wilson | Zendy; Matthew C. Garrett | Zendy; Bret Harry | Zendy; Jack Mottahedeh | Zendy; Phioanh L. Nghiemphu | Zendy; Harley I. Kornblum | Zendy; Paul S. Mischel | Zendy; Robert M. Prins | Zendy; William H. Yong | Zendy; Timothy F. Cloughesy | Zendy; Stanley F. Nelson | Zendy; Linda M. Liau | Zendy; Albert Lai | Zendy

Open Access

Identification of Retinol Binding Protein 1 Promoter Hypermethylation in Isocitrate Dehydrogenase 1 and 2 Mutant Gliomas

Author(s) -

Arthur P. Chou,

Reshmi Chowdhury,

Sichen Li,

Weidong Chen,

Andrew J. Kim,

David Piccioni,

Julia Selfridge,

Reema Mody,

Stephen Chang,

Shadi Lalezari,

Jeffrey Lin,

Desiree E. Sanchez,

Ryan W. Wilson,

Matthew C. Garrett,

Bret Harry,

Jack Mottahedeh,

Phioanh L. Nghiemphu,

Harley I. Kornblum,

Paul S. Mischel,

Robert M. Prins,

William H. Yong,

Timothy F. Cloughesy,

Stanley F. Nelson,

Linda M. Liau,

Albert Lai

Publication year - 2012

Publication title -

jnci journal of the national cancer institute

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.797

H-Index - 356

eISSN - 1460-2105

pISSN - 0027-8874

DOI - 10.1093/jnci/djs357

Subject(s) - idh2 , isocitrate dehydrogenase , idh1 , methylation , dna methylation , biology , cancer research , cpg site , bisulfite sequencing , microbiology and biotechnology , glioma , genetics , mutant , gene , gene expression , biochemistry , enzyme

Mutations in isocitrate dehydrogenase 1 (IDH1) and associated CpG island hypermethylation represent early events in the development of low-grade gliomas and secondary glioblastomas. To identify candidate tumor suppressor genes whose promoter methylation may contribute to gliomagenesis, we compared methylation profiles of IDH1 mutant (MUT) and IDH1 wild-type (WT) tumors using massively parallel reduced representation bisulfite sequencing.

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