Role of the Tripartite Motif Protein 27 in Cancer Development | Zendy

Georgia Zoumpoulidou | Zendy; Cristina Broceño | Zendy; Li He | Zendy; D. K. Bird | Zendy; George Thomas | Zendy; Sibylle Mittnacht | Zendy

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Role of the Tripartite Motif Protein 27 in Cancer Development

Author(s) -

Georgia Zoumpoulidou,

Cristina Broceño,

Li He,

D. K. Bird,

George Thomas,

Sibylle Mittnacht

Publication year - 2012

Publication title -

jnci journal of the national cancer institute

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.797

H-Index - 356

eISSN - 1460-2105

pISSN - 0027-8874

DOI - 10.1093/jnci/djs224

Subject(s) - repressor , biology , transcription factor , cancer research , genetics , gene

The tripartite motif family protein 27 (TRIM27) is a transcriptional repressor that interacts with, and attenuates senescence induction by, the retinoblastoma-associated protein (RB1). High expression of TRIM27 was noted in several human cancer types including breast and endometrial cancer, where elevated TRIM27 expression predicts poor prognosis. Here, we investigated the role of TRIM27 expression in cancer development.

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