Telomerase Reverse Transcriptase Locus Polymorphisms and Cancer Risk: A Field Synopsis and Meta-Analysis
Author(s) -
Simone Mocellin,
Daunia Verdi,
Karen A. Pooley,
Maria T. Landi,
Kathleen M. Egan,
Duncan M. Baird,
Jennifer Prescott,
Immaculata De Vivo,
Donato Nitti
Publication year - 2012
Publication title -
jnci journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/djs222
Subject(s) - telomerase reverse transcriptase , reverse transcriptase , meta analysis , locus (genetics) , telomerase , genetics , biology , medicine , computational biology , polymerase chain reaction , gene
Several recent studies have provided evidence that polymorphisms in the telomerase reverse transcriptase (TERT) gene sequence are associated with cancer development, but a comprehensive synopsis is not available. We conducted a systematic review and meta-analysis of the available molecular epidemiology data regarding the association between TERT locus polymorphisms and predisposition to cancer.
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