Open AccessLoss of Rho GDIα and Resistance to Tamoxifen via Effects on Estrogen Receptor α
Author(s) -
Ines Barone,
Lauren Brusco,
Guowei Gu,
Jennifer Selever,
Amanda Beyer,
Kyle R. Covington,
Anna Tsimelzon,
Tao Wang,
Susan G. Hilsenbeck,
Gary C. Chamness,
Sebastiano Andò,
Suzanne A.W. Fuqua
Publication year - 2011
Publication title -
journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/djr058
Subject(s) - tamoxifen , breast cancer , antiestrogen , toremifene , medicine , estrogen receptor , cancer research , metastasis , metastatic breast cancer , endocrinology , oncology , cancer
Estrogen receptor (ER) α is a successful therapeutic target in breast cancer, but patients eventually develop resistance to antiestrogens such as tamoxifen.