Open AccessMultifunctional Nanoparticles for Combining Ultrasonic Tumor Imaging and Targeted Chemotherapy
Author(s) -
Natalya Rapoport,
Zhonggao Gao,
Anne Kennedy
Publication year - 2007
Publication title -
journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/djm043
Subject(s) - microbubbles , doxorubicin , ultrasound , in vivo , micelle , drug delivery , biomedical engineering , nanoparticle , mechanical index , materials science , biophysics , chemistry , chemotherapy , nanotechnology , medicine , radiology , surgery , aqueous solution , microbiology and biotechnology , biology
Drug delivery in polymeric micelles combined with tumor irradiation by ultrasound results in effective drug targeting, but this technique requires prior tumor imaging. A technology that combined ultrasound imaging with ultrasound-mediated nanoparticle-based targeted chemotherapy could therefore have important applications in cancer treatment.