Open AccessQuantitation of Promoter Methylation of Multiple Genes in Urine DNA and Bladder Cancer Detection
Author(s) -
Mohammad O. Hoque,
Shahnaz Begum,
Özlem Topaloglu,
Aditi Chatterjee,
Eli Rosenbaum,
Wim Van Criekinge,
William H. Westra,
Mark Schoenberg,
Marianna Zahurak,
Steven N. Goodman,
David Sidransky
Publication year - 2006
Publication title -
journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/djj265
Subject(s) - bladder cancer , gstp1 , dna methylation , cdkn2a , methylation , cancer , biology , cancer research , polymerase chain reaction , gene , bisulfite sequencing , oncology , medicine , microbiology and biotechnology , genetics , genotype , gene expression
The noninvasive identification of bladder tumors may improve disease control and prevent disease progression. Aberrant promoter methylation (i.e., hypermethylation) is a major mechanism for silencing tumor suppressor genes and other cancer-associated genes in many human cancers, including bladder cancer.