Open AccessThe Association Between Antibiotic Use and Outcome Among Metastatic Melanoma Patients Receiving Immunotherapy
Author(s) -
Florence Poizeau,
Sandrine Kerbrat,
Frédéric Balusson,
Pierre Tattevin,
Matthieu Revest,
Vincent Cattoir,
David Luque Paz,
Thierry Lesimple,
Marc Pracht,
M. Dinulescu,
David Russo,
Emmanuel Oger,
Alain Dupuy
Publication year - 2022
Publication title -
journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/djac019
Subject(s) - medicine , hazard ratio , antibiotics , discontinuation , cohort , confidence interval , oncology , proportional hazards model , cohort study , microbiology and biotechnology , biology
Several observational studies have reported a decreased response to immune checkpoint inhibitors (ICI) following antibiotic use. ICI activity has been hypothesized to be impaired by antibiotic-induced gut dysbiosis.