Open AccessAssociation Between Hemochromatosis (HFE) Gene Mutation Carrier Status and the Risk of Colon Cancer
Author(s) -
Nicholas J. Shaheen,
Lawrence M. Silverman,
Temitope O. Keku,
L. B. Lawrence,
Elizabeth M. Rohlfs,
Clyde F. Martin,
J. Galanko,
Robert S. Sandler
Publication year - 2003
Publication title -
jnci journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/95.2.154
Subject(s) - hereditary hemochromatosis , medicine , colorectal cancer , odds ratio , hemochromatosis , gastroenterology , case control study , cancer , confidence interval , body mass index , genotype , population , allele , genetics , gene , biology , environmental health
Iron is a pro-oxidant that may promote carcinogenesis. Mutations in the hemochromatosis (HFE) gene are associated with increased total body iron stores in some individuals. We assessed the risk of colon cancer among individuals with and without HFE gene mutations.
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