Open AccessCellular Retinol-Binding Protein Expression and Breast Cancer
Author(s) -
Yuvarani S. Kuppumbatti,
Ira J. Bleiweiss,
John Mandeli,
Samuel Waxman,
Rafael Mira-y-Lopez
Publication year - 2000
Publication title -
journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/92.6.475
Subject(s) - retinoic acid , carcinogenesis , biology , pathology , ductal carcinoma , reduction mammoplasty , breast cancer , vitamin , receptor , cancer , retinol , in situ hybridization , medicine , cancer research , endocrinology , messenger rna , biochemistry , gene
The biologic activity of vitamin A depends, in part, on its metabolism to active nuclear receptor ligands, chiefly retinoic acid. The cellular retinol-binding protein (CRBP) binds vitamin A with high affinity and is postulated to regulate its uptake and metabolism. In this report, we analyze the expression of CRBP in normal and malignant breast tissues.