Open AccessImmunologic Proliferation Marker Ki-S2 as Prognostic Indicator for Lymph Node-Negative Breast Cancer
Author(s) -
P. Rudolph,
Per Alm,
H J Heidebrecht,
H. Bolte,
Virgo Ratjen,
Bo Baldetorp,
Mårten Fernö,
Håkan Olsson,
Reza Parwaresch
Publication year - 1999
Publication title -
jnci journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/91.3.271
Subject(s) - breast cancer , lymph node , proliferation index , immunohistochemistry , cancer , medicine , monoclonal antibody , oncology , flow cytometry , ki 67 , pathology , proliferation marker , antigen , antibody , immunology
Proper treatment of lymph node-negative breast cancer depends on an accurate prognosis. To improve prognostic models for this disease, we evaluated whether an immunohistochemical marker for proliferating cells, Ki-S2 (a monoclonal antibody that binds to a 100-kd nuclear protein expressed in S, G2, and M phases of the cell cycle), is an accurate indicator of prognosis.
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