Plasma Levels of Insulin-Like Growth Factor-I and Lung Cancer Risk: a Case-Control Analysis | Zendy

HongRen Yu | Zendy; M R Spitz | Zendy; Jehangir Mistry | Zendy; Jun Gu | Zendy; Waun Ki Hong | Zendy; Xin Wu | Zendy

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Plasma Levels of Insulin-Like Growth Factor-I and Lung Cancer Risk: a Case-Control Analysis

Author(s) -

HongRen Yu,

M R Spitz,

Jehangir Mistry,

Jun Gu,

Waun Ki Hong,

Xin Wu

Publication year - 1999

Publication title -

jnci journal of the national cancer institute

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.797

H-Index - 356

eISSN - 1460-2105

pISSN - 0027-8874

DOI - 10.1093/jnci/91.2.151

Subject(s) - lung cancer , medicine , quartile , odds ratio , oncology , case control study , cancer , risk factor , insulin like growth factor , confidence interval , univariate analysis , lung , endocrinology , gastroenterology , growth factor , multivariate analysis , receptor

Insulin-like growth factors (IGFs), in particular IGF-I and IGF-II, strongly stimulate the proliferation of a variety of cancer cells, including those from lung cancer. To examine the possible causal role of IGFs in lung cancer development, we compared plasma levels of IGF-I, IGF-II, and an IGF-binding protein (IGFBP-3) in patients with newly diagnosed lung cancer and in control subjects.

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