Growth Regulation of Prostatic Stromal Cells by Prostate-Specific Antigen | Zendy

Debra M. Sutkowski | Zendy; Robin L. Goode | Zendy; Jack Baniel | Zendy; Carroll Teater | Zendy; Pinchas Cohen | Zendy; A. McNulty | Zendy; Hansen M. Hsiung | Zendy; Gerald W. Becker | Zendy; Blake Lee Neubauer | Zendy

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Growth Regulation of Prostatic Stromal Cells by Prostate-Specific Antigen

Author(s) -

Debra M. Sutkowski,

Robin L. Goode,

Jack Baniel,

Carroll Teater,

Pinchas Cohen,

A. McNulty,

Hansen M. Hsiung,

Gerald W. Becker,

Blake Lee Neubauer

Publication year - 1999

Publication title -

jnci journal of the national cancer institute

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.797

H-Index - 356

eISSN - 1460-2105

pISSN - 0027-8874

DOI - 10.1093/jnci/91.19.1663

Subject(s) - stromal cell , igfbp3 , growth factor , endocrinology , medicine , cell growth , chemistry , hyperplasia , prostate specific antigen , prostate cancer , biology , receptor , biochemistry , cancer

Prostate-specific antigen (PSA) is a serine protease that can cleave insulin-like growth factor-binding protein-3 (IGFBP3), thereby decreasing its affinity for insulin-like growth factor-I (IGF-I). Dissociation of the IGF-I-IGFBP3 complex renders IGF-I available to bind to its receptor and stimulates cellular proliferation. We evaluated the potential for PSA to modulate the effects of IGF-I and IGFBP3 on the proliferation of human benign prostatic hyperplasia (BPH)-derived fibromuscular stromal cells in primary cultures.

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