Open AccessArsenic Trioxide as an Inducer of Apoptosis and Loss of PML/RARα Protein in Acute Promyelocytic Leukemia Cells
Author(s) -
Wenlin Shao,
Mirco Fanelli,
Fabiana Fosca Ferrara,
Roberta Riccioni,
Angelika Rosenauer,
Kelly Davison,
William W. Lamph,
Samuel Waxman,
Pier Giuseppe Pelicci,
Francesco LoCoco,
Giuseppe Avvisati,
Ugo Testy,
C Peschle,
Carlo GambacortiPasserini,
Clara Nervi,
Wilson H. Miller
Publication year - 1998
Publication title -
jnci journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/90.2.124
Subject(s) - arsenic trioxide , acute promyelocytic leukemia , retinoic acid , microbiology and biotechnology , apoptosis , tretinoin , cancer research , leukemia , promyelocytic leukemia protein , retinoic acid receptor alpha , biology , dna fragmentation , chemistry , retinoic acid receptor , programmed cell death , biochemistry , immunology , gene
Retinoids, which are derivatives of vitamin A, induce differentiation of acute promyelocytic leukemia (APL) cells in vitro and in patients. However, APL cells develop resistance to retinoic acid treatment. Arsenic trioxide (As2O3) can induce clinical remission in patients with APL, including those who have relapsed after retinoic acid treatment, by inducing apoptosis (programmed cell death) of the leukemia cells. In this study, we investigated the molecular mechanisms by which As2O3 induces apoptosis in retinoic acid-sensitive NB4 APL cells, in retinoic acid-resistant derivatives of these cells, and in fresh leukemia cells from patients.
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