Association of Prostate Cancer Risk With Genetic Polymorphisms in Vitamin D Receptor and Androgen Receptor | Zendy

Sue A. Ingles | Zendy; R K Ross | Zendy; M C Yu | Zendy; R. W. Haile | Zendy; Ryan A. Irvine | Zendy; Giuseppe Pera | Zendy; Gerhard A. Coetzee | Zendy

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Association of Prostate Cancer Risk With Genetic Polymorphisms in Vitamin D Receptor and Androgen Receptor

Author(s) -

Sue A. Ingles,

R K Ross,

M C Yu,

R. W. Haile,

Ryan A. Irvine,

Giuseppe Pera,

Gerhard A. Coetzee

Publication year - 1997

Publication title -

jnci journal of the national cancer institute

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.797

H-Index - 356

eISSN - 1460-2105

pISSN - 0027-8874

DOI - 10.1093/jnci/89.2.166

Subject(s) - prostate cancer , calcitriol receptor , androgen receptor , allele , odds ratio , oncology , medicine , prostate , cancer , genotype , biology , testosterone (patch) , endocrinology , vitamin d and neurology , genetics , gene

Prostate cancer is an increasingly common disease for which there are few well-established risk factors. Family history data suggest a genetic component; however, the majority of prostate cancer cases cannot be explained by a single-gene model. Prostate cell division is influenced by two steroid hormones, testosterone and vitamin D, the action of each being mediated by its respective receptor. The genes for the two receptors are candidates in a multigenic model for prostate cancer susceptibility.

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