Open AccessChanges in Integrin and E-Cadherin Expression in Neoplastic Versus Normal Thyroid Tissue
Author(s) -
Guido Serini,
Livio Trusolino,
Enrico Saggiorato,
Ottavio Cremona,
Marco Rossi,
A Angeli,
Fabio Orlandi,
Pier Carlo Marchisio
Publication year - 1996
Publication title -
journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/88.7.442
Subject(s) - integrin , laminin , pathology , biology , cell adhesion molecule , basement membrane , cadherin , microbiology and biotechnology , extracellular matrix , cell , medicine , biochemistry
BACK: The functional organization of polarized epithelia depends mostly on adhesion molecules belonging to the integrin and cadherin families. These molecules either recognize basement membrane components, such as laminins, or form intercellular junctions via homotypic interactions. Such tissue organization is often disrupted upon neoplastic transformation, and the resulting loss of functional polarization and cell cohesion might be a prerequisite for the invasive and metastatic behavior of carcinomas.