Open AccessIdentification of Selenoprotein H Isoforms and Impact of Selenoprotein H Overexpression on Protein But Not mRNA Levels of 2 Other Selenoproteins in 293T Cells
Author(s) -
Lei Cao,
Tibor Pechan,
Sang Gil Lee,
WenHsing Cheng
Publication year - 2021
Publication title -
journal of nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.463
H-Index - 265
eISSN - 1541-6100
pISSN - 0022-3166
DOI - 10.1093/jn/nxab290
Subject(s) - selenoprotein , microbiology and biotechnology , thioredoxin reductase , immunoprecipitation , thioredoxin , transfection , biology , gene isoform , chemistry , biochemistry , oxidative stress , gene , glutathione peroxidase , superoxide dismutase
Selenoprotein H (SELONOH), a member of the thioredoxin-like family proteins, is prioritized to degradation in selenium (Se) insufficiency. Recent studies implicate protective roles of SELENOH in oxidative stress, cellular senescence, and intestinal tumorigenesis. Although the nonselenoprotein H0YE28 is suggested as shortened SELENOH according to genomic and proteomic data repositories, this variant has not been verified biochemically.
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