Reduced Shmt2 Expression Impairs Mitochondrial Folate Accumulation and Respiration, and Leads to Uracil Accumulation in Mouse Mitochondrial DNA | Zendy

Joanna Fiddler | Zendy; Yuwen Xiu | Zendy; Jamie Blum | Zendy; Simon G. Lamarre | Zendy; Whitney N. Phinney | Zendy; Sally P. Stabler | Zendy; Margaret E. Brosnan | Zendy; John T. Brosnan | Zendy; Anna ThalackerMercer | Zendy; Martha S. Field | Zendy

Open Access

Reduced Shmt2 Expression Impairs Mitochondrial Folate Accumulation and Respiration, and Leads to Uracil Accumulation in Mouse Mitochondrial DNA

Author(s) -

Joanna Fiddler,

Yuwen Xiu,

Jamie Blum,

Simon G. Lamarre,

Whitney N. Phinney,

Sally P. Stabler,

Margaret E. Brosnan,

John T. Brosnan,

Anna ThalackerMercer,

Martha S. Field

Publication year - 2021

Publication title -

journal of nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.463

H-Index - 265

eISSN - 1541-6100

pISSN - 0022-3166

DOI - 10.1093/jn/nxab211

Subject(s) - mitochondrial dna , uracil , respiration , mitochondrion , biology , dna , microbiology and biotechnology , biochemistry , chemistry , gene , botany

Adequate cellular thymidylate (dTMP) pools are essential for preservation of nuclear and mitochondrial genome stability. Previous studies have indicated that disruption in nuclear dTMP synthesis leads to increased uracil misincorporation into DNA, affecting genome stability. To date, the effects of impaired mitochondrial dTMP synthesis in nontransformed tissues have been understudied.

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