Open AccessThe Inhibition of Metabolic Inflammation by EPA Is Associated with Enhanced Mitochondrial Fusion and Insulin Signaling in Human Primary Myotubes
Author(s) -
Domenico Sergi,
Natalie D. LuscombeMarsh,
Leonie K. Heilbronn,
Mark A. BirchMachin,
Nenad Naumovski,
Lillà Lionetti,
Christopher G. Proud,
Mahinda Y. Abeywardena,
Nathan J. O’Callaghan
Publication year - 2020
Publication title -
journal of nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.463
H-Index - 265
eISSN - 1541-6100
pISSN - 0022-3166
DOI - 10.1093/jn/nxaa430
Subject(s) - inflammation , myogenesis , insulin , mitochondrial fusion , mitochondrion , primary (astronomy) , microbiology and biotechnology , signal transduction , chemistry , endocrinology , biology , medicine , biochemistry , mitochondrial dna , myocyte , gene , astronomy , physics
Sustained fuel excess triggers low-grade inflammation that can drive mitochondrial dysfunction, a pivotal defect in the pathogenesis of insulin resistance in skeletal muscle.
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