Open AccessInsulinemic Potential of Lifestyle Is Inversely Associated with Leukocyte Mitochondrial DNA Copy Number in US White Adults
Author(s) -
Keming Yang,
Michele R. Forman,
Patrick O. Monahan,
Brett H. Graham,
Andrew T. Chan,
Xuehong Zhang,
Immaculata De Vivo,
Edward L. Giovannucci,
Fred K. Tabung,
Hongmei Nan
Publication year - 2020
Publication title -
journal of nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.463
H-Index - 265
eISSN - 1541-6100
pISSN - 0022-3166
DOI - 10.1093/jn/nxaa146
Subject(s) - mitochondrial dna , white (mutation) , genetics , biology , dna , mitochondrion , medicine , gerontology , endocrinology , physiology , gene
Poor lifestyles have been linked to insulin insensitivity/hyperinsulinemia, which may contribute to downstream changes such as inflammation and oxidative damage and the development of chronic diseases. As a biomarker of intracellular oxidative stress, leukocyte mitochondrial DNA copy number (mtDNA-CN) has been related to lifestyle factors including diet and weight. No epidemiologic study has examined the relation between combined insulinemic potential of lifestyle and mtDNA-CN.
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