Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach | Zendy

Shigeo Masuda | Zendy; Jun Wu | Zendy; Tomoaki Hishida | Zendy; Ganesh N. Pandian | Zendy; Hiroshi Sugiyama | Zendy; Juan Carlos Izpisúa Belmonte | Zendy

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Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach

Author(s) -

Shigeo Masuda,

Jun Wu,

Tomoaki Hishida,

Ganesh N. Pandian,

Hiroshi Sugiyama,

Juan Carlos Izpisúa Belmonte

Publication year - 2013

Publication title -

journal of molecular cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.825

H-Index - 62

eISSN - 1674-2788

pISSN - 1759-4685

DOI - 10.1093/jmcb/mjt034

Subject(s) - reprogramming , induced pluripotent stem cell , somatic cell , transgene , microbiology and biotechnology , biology , stem cell , embryonic stem cell , gene , genetics

Induced pluripotent stem cells (iPSCs) could be generated by a single gene Oct4 and chemical compounds, in which exogenous expression of Oct4 was indispensable for reprogramming. Recent advances in chemical-mediated cellular reprogramming suggest that small molecules alone (i.e. without Yamanaka factors) can successfully establish iPSCs from mouse somatic cells.

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