H3K9me2 attracts PGC7 in the zygote to prevent Tet3-mediated oxidation of 5-methylcytosine | Zendy

Piroska E. Szabó | Zendy; Gerd P. Pfeifer | Zendy

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H3K9me2 attracts PGC7 in the zygote to prevent Tet3-mediated oxidation of 5-methylcytosine

Author(s) -

Piroska E. Szabó,

Gerd P. Pfeifer

Publication year - 2012

Publication title -

journal of molecular cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.825

H-Index - 62

eISSN - 1674-2788

pISSN - 1759-4685

DOI - 10.1093/jmcb/mjs038

Subject(s) - reprogramming , 5 hydroxymethylcytosine , 5 methylcytosine , pronucleus , zygote , epigenetics , oocyte , histone , biology , microbiology and biotechnology , dna methylation , genetics , dna demethylation , dna , chemistry , gene , embryo , embryogenesis , gene expression

Epigenetic reprogramming of the parental genome occurs in fertilized oocytes and involves oxidation of 5-methylcytosines (5-mC) to 5-hydroxymethylcytosines (5-hmC) in the paternal pronucleus. Recent work has shown that the maternal genome is protected from this remodeling step by an interaction between a modified histone, H3K9me2, and the oocyte-derived factor, PGC7, to prevent oxidation of the maternal DNA by the Tet3 5-methylcytosine oxidase.

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