EMT and MET as paradigms for cell fate switching | Zendy

Jiekai Chen | Zendy; Qun Han | Zendy; Dong Pei | Zendy

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EMT and MET as paradigms for cell fate switching

Author(s) -

Jiekai Chen,

Qun Han,

Dong Pei

Publication year - 2011

Publication title -

journal of molecular cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.825

H-Index - 62

eISSN - 1674-2788

pISSN - 1759-4685

DOI - 10.1093/jmcb/mjr045

Subject(s) - reprogramming , cell fate determination , mesenchymal stem cell , epithelial–mesenchymal transition , biology , microbiology and biotechnology , induced pluripotent stem cell , cell , embryonic stem cell , transition (genetics) , genetics , transcription factor , gene

Cell fate determination is a major unsolved problem in cell and developmental biology. The discovery of reprogramming by pluripotent factors offers a rational system to investigate the molecular mechanisms associated with cell fate decisions. The idea that reprogramming of fibroblasts starts with a mesenchymal-epithelial transition (MET) suggests that the process is perhaps a reversal of epithelial to mesenchymal transition (EMT) found frequently during early embryogenesis. As such, we believe that investigations into MET-EMT may yield detailed molecular insights into cell fate decisions, not only for the switching between epithelial and mesenchymal cells, but also other cell types.

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