Ripoptosome: a novel IAP-regulated cell death-signalling platform | Zendy

G. Imre | Zendy; Sarit Larisch | Zendy; K. Rajalingam | Zendy

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Ripoptosome: a novel IAP-regulated cell death-signalling platform

Author(s) -

G. Imre,

Sarit Larisch,

K. Rajalingam

Publication year - 2011

Publication title -

journal of molecular cell biology

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.825

H-Index - 62

eISSN - 1674-2788

pISSN - 1759-4685

DOI - 10.1093/jmcb/mjr034

Subject(s) - necroptosis , microbiology and biotechnology , programmed cell death , xiap , kinase , apoptosis , signal transduction , ripk1 , ubiquitin , cytosol , biology , phosphorylation , chemistry , caspase , biochemistry , enzyme , gene

Recent studies have revealed that cell death stimuli can trigger programmed necrosis, necroptosis. Receptor-interacting serine-threonine kinase family RIP plays a crucial role in regulating the switch between apoptosis and necroptosis. Two studies now describe a novel RIP1 containing ~2 MDa 'Ripoptosome' complex assembled in the cytosol to mediate both apoptosis and necroptosis in response to genotoxic stress and TLR3 stimulation. Intriguingly, cIAPs and XIAP function as endogenous inhibitors of Ripoptosome by direct ubiquitination of its components.

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