Open AccessApplications of post-translational modifications of FoxO family proteins in biological functions
Author(s) -
Ying Zhao,
Yachen Wang,
WeiGuo Zhu
Publication year - 2011
Publication title -
journal of molecular cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.825
H-Index - 62
eISSN - 1674-2788
pISSN - 1759-4685
DOI - 10.1093/jmcb/mjr013
Subject(s) - acetylation , ubiquitin , posttranslational modification , glycosylation , phosphorylation , biology , methylation , microbiology and biotechnology , computational biology , genetics , dna , biochemistry , gene , enzyme
The functions of the FoxO family proteins, in particular their transcriptional activities, are modulated by post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, methylation and glycosylation. These PTMs occur in response to different cellular stresses, which in turn regulate the subcellular localization of FoxO family proteins, as well as their half-life, DNA binding, transcriptional activity and ability to interact with other cellular proteins. In this review, we summarize the role of PTMs of FoxO family proteins in linking their biological and functional relevance with various diseases.
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