Purinergic Control of Neutrophil Activation | Zendy

Fabio Grassi | Zendy

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Purinergic Control of Neutrophil Activation

Author(s) -

Fabio Grassi

Publication year - 2010

Publication title -

journal of molecular cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.825

H-Index - 62

eISSN - 1674-2788

pISSN - 1759-4685

DOI - 10.1093/jmcb/mjq014

Subject(s) - purinergic receptor , purinergic signalling , microbiology and biotechnology , first line , adenosine triphosphate , signal transduction , biology , inflammation , receptor , immunology , chemistry , adenosine receptor , biochemistry , extracellular , medicine , agonist

Neutrophils constitute the first line of defense against invading pathogens, but they also are responsible for tissue destruction in pathological conditions. In a recent paper published in Science Signaling, Junger and colleagues show that adenosine 5'-triphosphate release and signaling through purinergic P2 receptors upon neutrophil activation by bacterial and inflammatory stimuli represents an important mechanism for effective neutrophil functional response and host protection.

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