Open AccessJanus Kinase 2: An Epigenetic 'Writer' that Activates Leukemogenic Genes
Author(s) -
Jin He,
Yi Zhang
Publication year - 2010
Publication title -
journal of molecular cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.825
H-Index - 62
eISSN - 1674-2788
pISSN - 1759-4685
DOI - 10.1093/jmcb/mjp054
Subject(s) - chromatin , histone , janus kinase 2 , microbiology and biotechnology , epigenetics , biology , ezh2 , heterochromatin protein 1 , genetics , phosphorylation , gene , heterochromatin
Activation of Janus kinase 2 (JAK2) plays a critical role in normal hematopoiesis and leukemogenesis. Dawson et al. (2009; JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461, 819-822) report that JAK2 performs this function by displacing the heterochromatin protein HP1α from chromatin through phosphorylation of histone H3.
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