Novel Proteasome Inhibitors as Potential Drugs to Combat Tuberculosis | Zendy

Cheng Yang | Zendy; Jean Pieters | Zendy

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Novel Proteasome Inhibitors as Potential Drugs to Combat Tuberculosis

Author(s) -

Cheng Yang,

Jean Pieters

Publication year - 2010

Publication title -

journal of molecular cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.825

H-Index - 62

eISSN - 1674-2788

pISSN - 1759-4685

DOI - 10.1093/jmcb/mjp053

Subject(s) - proteasome , mycobacterium tuberculosis , tuberculosis , nitric oxide , biology , microbiology and biotechnology , computational biology , chemistry , medicine , pathology , endocrinology

Mycobacterium tuberculosis is one of the most notorious killers worldwide. These pathogens have evolved to infect human beings in a so-called dormant form that is extremely difficult to treat. New work, however, suggests that mycobacterial proteasomes, multicomponent structures that protect the microbe from damaging effects of nitric oxide generated by the host, can be selectively and specifically blocked by small molecules.

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