Open AccessSTING-ing the Antiviral Pathway
Author(s) -
Peyman Nakhaei,
John Hiscott,
Rongtuan Lin
Publication year - 2009
Publication title -
journal of molecular cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.825
H-Index - 62
eISSN - 1674-2788
pISSN - 1759-4685
DOI - 10.1093/jmcb/mjp048
Subject(s) - sting , dna , biology , dna damage , microbiology and biotechnology , stimulator of interferon genes , cytosol , computational biology , genetics , virology , innate immune system , biochemistry , immune system , engineering , enzyme , aerospace engineering
The cytosolic DNA sensing pathway has remained poorly defined thus far. A recent study by Ishikawa et al. demonstrates that STING is essential for DNA-mediated type I IFN production and host defence against DNA pathogens.
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