WD40 Repeats Arrange Histone Tails for Spreading of Silencing | Zendy

Tatsuo Suganuma | Zendy; Jerry L. Workman | Zendy

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WD40 Repeats Arrange Histone Tails for Spreading of Silencing

Author(s) -

Tatsuo Suganuma,

Jerry L. Workman

Publication year - 2009

Publication title -

journal of molecular cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.825

H-Index - 62

eISSN - 1674-2788

pISSN - 1759-4685

DOI - 10.1093/jmcb/mjp046

Subject(s) - prc2 , enhancer , biology , genetics , hox gene , repressor , homeobox , histone , histone h3 , microbiology and biotechnology , gene silencing , polycomb group proteins , gene , gene expression

Direct binding of WD40 repeat of Embryonic Ectoderm Development (EED) in the Polycomb Repressor Complex 2 (PRC2) to the histone H3 tail regulates the H3K27 methyltrasnferase activity of PRC2. The binding activity is required for the methylation of H3K27 over long distance of a Drosophila chromosome from the UBX (Hox gene) promoter to the PBX upstream enhancer region, implying EED initiates propagation of this repressive mark.

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