Open AccessWhen It Comes to Antibiotics, Bacteria Show Some NO-how
Author(s) -
B. A. Patel,
Brian R. Crane
Publication year - 2010
Publication title -
journal of molecular cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.825
H-Index - 62
eISSN - 1674-2788
pISSN - 1759-4685
DOI - 10.1093/jmcb/mjp044
Subject(s) - bacteria , antibiotics , microbiology and biotechnology , biology , reactive oxygen species , nitric oxide , bacilli , oxidative phosphorylation , enzyme , biochemistry , genetics , endocrinology
Homologs to mammalian nitric oxide synthases are found in many mostly Gram-positive bacteria. In some genera such as bacilli, and staphylococci, these enzymes produce protects against oxidative damage, this effect has now been shown to provide an advantage against antibiotics that kill by increasing cellular levels of reactive oxygen species.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom