Neither Too Much Nor Too Little: Reactive Oxygen Species Levels Regulate Drosophila Hematopoiesis
Author(s) -
Alain Vincent,
Michèle Crozatier
Publication year - 2009
Publication title -
journal of molecular cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.825
H-Index - 62
eISSN - 1674-2788
pISSN - 1759-4685
DOI - 10.1093/jmcb/mjp042
Subject(s) - reactive oxygen species , haematopoiesis , microbiology and biotechnology , drosophila (subgenus) , biology , progenitor cell , stem cell , genetics , gene
Owing to their fast diffusion, reactive oxygen species (ROS) are important tissue signalling components. High levels of ROS are generally considered as deleterious to cells. In vivo experiments in the Drosophila hematopoietic organ now challenge this view by showing that high ROS levels are intrinsically required to prime myeloid-like progenitors to differentiate.
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