Identity Crisis When Telomeres Left Unprotected | Zendy

Yunyun Wu | Zendy; Virginia A. Zakian | Zendy

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Identity Crisis When Telomeres Left Unprotected

Author(s) -

Yunyun Wu,

Virginia A. Zakian

Publication year - 2009

Publication title -

journal of molecular cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.825

H-Index - 62

eISSN - 1674-2788

pISSN - 1759-4685

DOI - 10.1093/jmcb/mjp031

Subject(s) - telomere , identity crisis , biology , identity (music) , left behind , covid-19 , genetics , evolutionary biology , sociology , psychology , gene , medicine , philosophy , social science , aesthetics , mental health , disease , face (sociological concept) , infectious disease (medical specialty) , psychotherapist

Loss of shelterin components TRF2 or POT1a-TPP1 complex from the chromosome end triggers DNA damage response (DDR) and aberrant DNA repair events. In a recent Nature paper, Chang and colleagues reported that the DNA repair protein Mre11 contributes to multiple events at the uncapped telomere, including ataxia telangiectasia-mutated (ATM)-dependent signaling, processing of the telomeric G-tail and homologous recombination (HR).

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