Open AccessMacrophage Metalloelastase: Stretching Therapeutic Opportunities
Author(s) -
Jiangping He,
Menno van Lookeren Campagne
Publication year - 2009
Publication title -
journal of molecular cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.825
H-Index - 62
eISSN - 1674-2788
pISSN - 1759-4685
DOI - 10.1093/jmcb/mjp015
Subject(s) - macrophage , alveolar macrophage , immune system , microbiology and biotechnology , bacteria , biology , immunology , biochemistry , genetics , in vitro
While tissue macrophages are at the first line of microbial host defense, they are also convenient hideouts for pathogens escaping immune attack. Houghton et al. discovered that alveolar macrophage mobilizes macrophage metalloelastase to destroy bacteria present inside the cell.
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