Dynamic Balancing: DEPTOR Tips the Scales | Zendy

Christopher G. Proud | Zendy

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Dynamic Balancing: DEPTOR Tips the Scales

Author(s) -

Christopher G. Proud

Publication year - 2009

Publication title -

journal of molecular cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.825

H-Index - 62

eISSN - 1674-2788

pISSN - 1759-4685

DOI - 10.1093/jmcb/mjp012

Subject(s) - pi3k/akt/mtor pathway , regulator , downstream (manufacturing) , key (lock) , microbiology and biotechnology , biology , master regulator , signal transduction , cancer research , computational biology , genetics , gene , business , ecology , marketing , transcription factor

The mammalian target of rapamycin, mTOR, is a key node in cellular regulation: its dysregulation is important in a number of disease states, including various cancers. A recent study identifies a new partner and regulator of mTOR, which can alter the balance of signaling downstream of mTOR and appears to be important in certain cancers, such as multiple myelomas.

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