From Breast to the Brain: Unraveling the Puzzle of Metastasis Organotropism | Zendy

Guohong Hu | Zendy; Yibin Kang | Zendy; X.-F. Wang | Zendy

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From Breast to the Brain: Unraveling the Puzzle of Metastasis Organotropism

Author(s) -

Guohong Hu,

Yibin Kang,

X.-F. Wang

Publication year - 2009

Publication title -

journal of molecular cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.825

H-Index - 62

eISSN - 1674-2788

pISSN - 1759-4685

DOI - 10.1093/jmcb/mjp005

Subject(s) - metastasis , breast cancer , brain metastasis , breast cancer metastasis , stromal cell , identification (biology) , cancer metastasis , bone metastasis , biology , gene , cancer , computational biology , cancer research , genetics , ecology

Metastatic colonization of different target organs is a highly selective process that depends on specialized properties of tumor cells. In a recent Nature paper, Massagué and colleagues built on their earlier success in functional genomic analysis of breast cancer metastasis to bone and lung and reported the identification of breast cancer brain metastasis genes, highlighting the importance of the stromal environment in the development of organ-specific metastasis.

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