A novel isoform of ATOH8 promotes the metastasis of breast cancer by regulating RhoC | Zendy

Mengyao Xu | Zendy; Shan Huang | Zendy; Xiaoli Dong | Zendy; Yanan Chen | Zendy; Miao Li | Zendy; Wen Shi | Zendy; Guanwen Wang | Zendy; Chongbiao Huang | Zendy; Qiong Wang | Zendy; Yanhua Liu | Zendy; Peiqing Sun | Zendy; Shuang Yang | Zendy; Rong Xiang | Zendy; Antao Chang | Zendy

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A novel isoform of ATOH8 promotes the metastasis of breast cancer by regulating RhoC

Author(s) -

Mengyao Xu,

Shan Huang,

Xiaoli Dong,

Yanan Chen,

Miao Li,

Wen Shi,

Guanwen Wang,

Chongbiao Huang,

Qiong Wang,

Yanhua Liu,

Peiqing Sun,

Shuang Yang,

Rong Xiang,

Antao Chang

Publication year - 2020

Publication title -

journal of molecular cell biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.825

H-Index - 62

eISSN - 1674-2788

pISSN - 1759-4685

DOI - 10.1093/jmcb/mjaa050

Subject(s) - rhoc , metastasis , breast cancer , gene silencing , cancer research , metastatic breast cancer , cancer , biology , medicine , genetics , gene

Metastases are the main cause of cancer-related mortality in breast cancer. Although significant progress has been made in the field of tumor metastasis, the exact molecular mechanisms involved in tumor metastasis are still unclear. Here, we report that ATOH8-V1, a novel isoform of ATOH8, is highly expressed in breast cancer and is a negative prognostic indicator of survival for patients. Forced expression of ATOH8-V1 dramatically enhances, while silencing of ATOH8-V1 decreases the metastasis of breast cancer cell lines. Moreover, ATOH8-V1 directly binds to the RhoC promoter and stimulates the expression of RhoC, which in turn enhances the metastasis of breast cancer. Altogether, our data demonstrate that ATOH8-V1 is a novel pro-metastatic factor that enhances cancer metastasis, suggesting that ATOH8-V1 is a potential therapeutic target for treatment of metastatic cancers.

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