Open AccessDifferent Responses to Gefitinib in Lung Adenocarcinoma Coexpressing Mutant- and Wild-Type Epidermal Growth Factor Receptor Genes
Author(s) -
WenChi Chou,
Shiu-Feng Huang,
Kuo Wei Yeh,
HungMing Wang,
Meiying Liu,
JiaJuan Hsieh,
YunChung Cheung,
John WenCheng Chang
Publication year - 2006
Publication title -
japanese journal of clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.768
H-Index - 85
eISSN - 1465-3621
pISSN - 0368-2811
DOI - 10.1093/jjco/hyl057
Subject(s) - gefitinib , epidermal growth factor receptor , mutant , cancer research , adenocarcinoma , medicine , wild type , lung cancer , gene , lung , mutation , epidermal growth factor , receptor , biology , cancer , genetics
Response to gefitinib is strongly associated with the status of the epidermal growth factor receptor gene. Here we report the different treatment responses in a case of lung adenocarcinoma coexpressing mutant-type gene in the primary lung mass and a wild-type gene in the metastatic bone lesions. This case demonstrated that at least two strains of tumor cells were present in a single patient. This may be one of the mechanisms of gefitinib resistance.