Glu346Lys Polymorphism in the Methyl-CpG Binding Domain 4 Gene and the Risk of Primary Lung Cancer | Zendy

Moo Chul Shin | Zendy; Su Jeong Lee | Zendy; Jin Eun Choi | Zendy; Sung Ick | Zendy; Chang Ho Kim | Zendy; Won Kee Lee | Zendy; Sin Kam | Zendy; Young Mo Kang | Zendy; Tae Hoon Jung | Zendy; Jae Yong Park | Zendy

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Glu346Lys Polymorphism in the Methyl-CpG Binding Domain 4 Gene and the Risk of Primary Lung Cancer

Author(s) -

Moo Chul Shin,

Su Jeong Lee,

Jin Eun Choi,

Sung Ick,

Chang Ho Kim,

Won Kee Lee,

Sin Kam,

Young Mo Kang,

Tae Hoon Jung,

Jae Yong Park

Publication year - 2006

Publication title -

japanese journal of clinical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.768

H-Index - 85

eISSN - 1465-3621

pISSN - 0368-2811

DOI - 10.1093/jjco/hyl055

Subject(s) - genotype , lung cancer , odds ratio , medicine , confidence interval , allele , oncology , cancer research , gene , genetics , biology

Methyl-CpG binding domain 4 (MBD4) protein functions as a DNA repair enzyme and minimizes mutations at 5-methylcytosine. Polymorphisms in the DNA repair gene MBD4 may be associated with differences in DNA repair capacity and thereby influence an individual's susceptibility to lung cancer. To test this hypothesis, we examined the potential association between the MBD4 Glu346Lys polymorphism and the risk of lung cancer in a Korean population.

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