Practical genetic control strategies for industrial bioprocesses | Zendy

Jonathan C. Moore | Zendy; Itzel Ramos | Zendy; Stephen Van Dien | Zendy

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Practical genetic control strategies for industrial bioprocesses

Author(s) -

Jonathan C. Moore,

Itzel Ramos,

Stephen Van Dien

Publication year - 2022

Publication title -

journal of industrial microbiology and biotechnology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.857

H-Index - 112

eISSN - 1476-5535

pISSN - 1367-5435

DOI - 10.1093/jimb/kuab088

Subject(s) - biochemical engineering , microbiology and biotechnology , control (management) , biology , computational biology , engineering , computer science , artificial intelligence

Optimization of metabolism to maximize production of bio-based chemicals must consistently balance cellular resources for biocatalyst growth and desired compound synthesis. This mini-review discusses synthetic biology strategies for dynamically controlling expression of genes to enable dual-phase fermentations in which growth and production are separated into dedicated phases. Emphasis is placed on practical examples which can be reliably scaled to commercial production with the current state of technology. Recent case studies are presented, and recommendations are provided for environmental signals and genetic control circuits.

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