Open AccessEngineering robust microorganisms for organic acid production
Author(s) -
Vinh Tran,
Huimin Zhao
Publication year - 2021
Publication title -
journal of industrial microbiology and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.857
H-Index - 112
eISSN - 1476-5535
pISSN - 1367-5435
DOI - 10.1093/jimb/kuab067
Subject(s) - biochemical engineering , microorganism , fermentation , organic acid , microbiology and biotechnology , production (economics) , renewable resource , environmental science , pulp and paper industry , chemistry , renewable energy , organic chemistry , bacteria , biology , engineering , ecology , genetics , macroeconomics , economics
Organic acids are an important class of compounds that can be produced by microbial conversion of renewable feedstocks and have huge demands and broad applications in food, chemical, and pharmaceutical industries. An economically viable fermentation process for production of organic acids requires robust microbial cell factories with excellent tolerance to low pH conditions, high concentrations of organic acids, and lignocellulosic inhibitors. In this review, we summarize various strategies to engineer robust microorganisms for organic acid production and highlight their applications in a few recent examples.
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